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KMID : 1130320080510070742
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Korean Journal of Pediatrics
2008 Volume.51 No. 7 p.742 ~ p.746
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Effects and adverse-effects of growth hormone therapy in children with Prader-Willi syndrome: A two year study
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Kim Su-Jin
Cho Joong-Bum
Kwak Min-Jung
Paik Kyung-Hoon
Kwon Eun-Kyung
Jin Dong-Kyu
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Abstract
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Purpose : The objective of this study was to evaluate the effects and adverse side-effects of growth hormone (GH) therapy in children with Prader-Willi syndrome (PWS).
Methods : Forty-one patients who had been treated with GH for more than two years (24 boys and 17 girls, mean age 7.3?.3 years during treatment initiation) were enrolled for this study.
Results : After 2 years of GH therapy, the height and weight standard deviation scores (SDS) increased significantly (?.19?.37 vs. ?.02?.45, and 1.02?.42 vs. 1.63?.22, P<0.002); however the percentage body fat decreased (44.6?.9% vs. 38.1?0.5%, P<0.001). Further, no change was observed in the thyroid and serum glucose levels, but the total cholesterol level decreased. GH therapy did not impact glucose control in the patients with diabetes. The most common adverse effects of GH therapy were the progression of scoliosis and adenoid hypertrophy.
Conclusion :
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KEYWORD
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Prader-Willi syndrome, Growth hormone, Growth hormone therapy, Adverse effect
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